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Description
The story of the search for p53--the most important gene in medicine.
All of us have lurking in our DNA a most remarkable gene: it is known simply as p53 and its job is to protect us from cancer. p53: The Gene that Cracked the Cancer Code tells the story of the discovery of the gene and of medical science's mission to unravel its mysteries and get to the heart of what happens in our cells when they turn cancerous. When all is well, this gene constantly scans our cells to ensure that when they grow and divide as part of the routine maintenance of our bodies, they do so without mishap. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, sending in the repair team before allowing the cell to carry on dividing. Cancer cannot develop unless p53 itself is damaged or handicapped by some other fault in the system. Not surprisingly, p53 is the most studied single gene in history.
Through the personal accounts of key researchers, the book reveals the excitement of the hunt for new cures--the hype, the enthusiasm, the lost opportunities, the blind alleys and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is at the cutting edge. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.
Product details
Published | Feb 24 2015 |
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Format | Hardback |
Edition | 1st |
Extent | 288 |
ISBN | 9781472910516 |
Imprint | Bloomsbury Sigma |
Dimensions | 9 x 5 inches |
Publisher | Bloomsbury Publishing |
About the contributors
Reviews
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More than any textbook, article, or lecture could, this book offers a sip of contagious enthusiasm and a conviction that scientists will eventually “crack the cancer code"
Science
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One of the best accounts I've read of how science is actually performed.
Peter Forbes, The Guardian
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A succinct, accessible study of humanity's genetic bulwark against cancer.
Nature
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Ms. Armstrong¹s book comes alive in the sections where she explores cancer¹s human toll, including the devastating experience of families with rare genetic mutations, such as Li-Fraumeni syndrome, which leaves children of parents with a faulty gene vulnerable to cancer at almost any age. She also captures the excitement of researchers as they come upon eureka moments.
Wall Street Journal
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Armstrong paints a very human picture ... Not only does Armstrong make p53 understandable but she also sheds light on the scientific method. In an age of government austerity, highlighting the importance of scientific research is also a gift.
The Lancet
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Armstrong has rendered, from what easily could have become a tangled web of complex science, a readable story of discovery. As in the best travel writing, it's not the destination that's important here, but the journey. This is not only a story about the gene on chromosome 17, nor only about the nature of cancer, but also about how science works.
Ellen Bartlett, Boston Globe

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